小動物復(fù)合肌肉動作電位采集系統(tǒng)
產(chǎn)品詳情介紹
總覽
iWorx RS-CMAP4-SA 專為研究復(fù)合肌肉動作電位 (CMAP) 和神經(jīng)傳導(dǎo)速度而設(shè)計。該系統(tǒng)還可用于4通道肌電圖 (EMG) 記錄，或肌電圖和心電圖 (ECG) 組合記錄。針對嚙齒動物和其他小動物的數(shù)據(jù)記錄進行了優(yōu)化。
產(chǎn)品特征
復(fù)合肌肉動作電位 (CMAP) 是神經(jīng)肌肉電生理研究中的重要指標(biāo)，指在刺激一條運動神經(jīng)后，在該神經(jīng)支配的肌肉上記錄到的多個肌纖維動作電位的總和。嚙齒動物的 CMAP 研究廣泛應(yīng)用于臨床前神經(jīng)科學(xué)和神經(jīng)肌肉研究，以評估運動神經(jīng)、神經(jīng)肌肉接頭和肌肉的功能。肌萎縮側(cè)索硬化癥 (ALS)、脊髓性肌萎縮癥 (SMA)、腓骨肌萎縮癥或周圍神經(jīng)病變等嚙齒動物疾病模型通常使用 CMAP 來追蹤疾病的發(fā)生和進展。坐骨神經(jīng)受擠壓或橫斷后，CMAP 記錄可以評估功能性神經(jīng)恢復(fù)的程度和時間。
刺激電極用于刺激特定的神經(jīng)組織，皮下針式電極放置在受神經(jīng)支配的肌肉組織上，軟件控制電刺激輸出，生物電放大器實時記錄肌電信號，專業(yè)的CMAP高級分析軟件模塊用于分析波形圖。
計算內(nèi)容包括：
最大值：所選動作電位的最大振幅電壓
最小值：所選動作電位的最小振幅電壓
起始潛伏期：從周期或刺激開始到波形圖首次偏離基線的時間
峰值潛伏期：從周期或刺激開始到波形圖到最高點的時間
峰值前最大導(dǎo)數(shù)：峰值前動作電位的最大導(dǎo)數(shù)
峰值前最小導(dǎo)數(shù)：峰值前動作電位的最小導(dǎo)數(shù)
峰值后最大導(dǎo)數(shù)：峰值后動作電位的最大導(dǎo)數(shù)
峰值后最小導(dǎo)數(shù)：峰值后動作電位的最小導(dǎo)數(shù)
波幅：正向波頂點到負(fù)向波谷底的電壓差
上升時間：從峰值開始到最大值的時間
最小時間：從峰值開始到最小值的時間
峰值停止：峰值結(jié)束的時間
周期持續(xù)時間：從峰值開始到峰值停止的時間
配置包括：
iWorx RA5s生理記錄儀
LabScribe數(shù)據(jù)采集分析軟件
EMG分析模塊
皮下針式信號采集電極
高壓皮下刺激電極
低壓皮下刺激電極
參考文獻
- Crouch, Michael S., Mingde Zheng, and Michael S. Eggleston. “Natural Typing Recognition vis Surface Electromyography.” arXiv preprint arXiv:2109.10743 (2021).
- Djabakatie, Zakiyat. “Function of spiny dorsal fin erector muscles in the bluegill, Lepomis macrochirus.” (2021).
- Yen, Patrick Szu-Ying, et al. “Upregulation of Glutamatergic Receptors in Hippocampus and Locomotor Hyperactivity in Aged Spontaneous Hypertensive Rat.” Cellular and Molecular Neurobiology (2021): 1-13.
- Bao, Xinqi, Aimé Kingwengwe Abdala, and Ernest Nlandu Kamavuako. “Estimation of the Respiratory Rate from Localised ECG at Different Auscultation Sites.” Sensors 21.1 (2021): 78.
- Zhang, Yi, et al. “Stretch-induced sarcoplasmic reticulum calcium leak is causatively associated with atrial fibrillation in pressure-overloaded hearts.” Cardiovascular research 117.4 (2021): 1091-1102.
- Ibsen, Lasse W., and Samuel Schmidt. “Seismocardiography as method for studying acute alcohol related hemodynamic changes.“(2020).
- Quint, Clay. “Tissue‐engineered vessel derived from human fibroblasts with an electrospun scaffold.” Journal of Tissue Engineering and Regenerative Medicine (2020).
- Bao, Xinqi, et al. “Comparison between Embroidered and Gel Electrodes on ECG-Derived Respiration Rate.” 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2020.
- Lee, Jiho, et al. “An Efficient Noninvasive Neuromodulation Modality for Overactive Bladder Using Time Interfering Current Method.” IEEE Transactions on Biomedical Engineering (2020).
- Hodge, Jacob, and Clay Quint. “Tissue engineered vessel from a biodegradable electrospun scaffold stimulated with mechanical stretch.” Biomedical Materials (2020).
- Lee, Hsiang-Chun, et al. “The sodium–glucose co-transporter 2 inhibitor empagliflozin attenuates cardiac fibrosis and improves ventricular hemodynamics in hypertensive heart failure rats.” Cardiovascular diabetology 18.1 (2019): 45.
- Azad, Md Khurshidul, et al. “Monitoring Intracranial Pressure Using Non-Invasive Brain Stethoscope.” SoutheastCon 2018. IEEE, 2018.
- Craighead, Daniel H., et al. “Ingestion of transient receptor potential channel agonists attenuates exercise‐induced muscle cramps.” Muscle & nerve 56.3 (2017): 379-385.
- Shiou, Yi-Lin, et al. “High fat diet aggravates atrial and ventricular remodeling of hypertensive heart disease in aging rats.” Journal of the Formosan Medical Association (2017).
- Munck, Kim, et al. “Body surface mapping of the mechanical cardiac activity.” Computing in Cardiology Conference (CinC), 2016. IEEE, 2016.
- Struijk, Johannes J., et al. “Heart-valve sounds obtained with a Laser Doppler Vibrometer.” Computing in Cardiology Conference (CinC), 2016. IEEE, 2016.
