HypoxyLab?
Bench-top physiological oxygen incubator and workstation
Description
Overview
In the field of tissue culture, there is a rapidly growing appreciation that a physiological cellular oxygen environment is essential for the analysis of cellular processes with respect to function and metabolism.
Rising to this challenge, Oxford Optronix has developed the HypoxyLab? - a fully-featured, ergonomically engineered and easy to use normoxia/hypoxia workstation that provides a HEPA-filtered environment in which oxygen, carbon dioxide, temperature and humidity can be precisely controlled.
In short, HypoxyLab? is a compact hypoxia workstation and incubator for everyday use, suitable for applications including,
Cancer, radiation and apoptosis cell biology
Stem cell research
Neurosciences research
Human virology research
Multidisciplinary drug development and proteomics
* 5-year manufacturer's warranty is conditional upon annual preventative maintenance servicing
Features
True physiological oxygen (Physoxia)
Rapid, efficient, accurate
In situ dissolved oxygen from media and cultures
Live cell imaging
Contamination control
Touchscreen display
Automated oxygen profiles
Data logging
Easy-entry system
Lightweight cover / Ergonomic design
Cost of ownership advantage
Journal Citations
(Updated: June 2021)
Rapid Evaluation of Novel Therapeutic Strategies Using a 3D Collagen-Based Tissue-Like Model. Maury P, Porcel E, Mau A, Lux F, Tillement O, Mahou P, Schanne-Klein MC, and Lacombe S (2021). Front Bioeng Biotechnol. 2021 Feb 16;9:574035. doi: 10.3389/fbioe.2021.574035. eCollection 2021
Differentiated cells in prolonged hypoxia produce highly infectious native-like hepatitis C virus particles (2021). Cochard J, Bull-Maurer A, Tauber C, Burlaud-Gaillard J, Mazurier F, Meunier J-C, Roingeard P and Chouteau P. Hepatology. 2021 Mar 4. doi: 10.1002/hep.31788. Online ahead of print
Impact of the acidic environment on gene expression and functional parameters of tumors in vitro and in vivo (2021). Rauschner M, Lange L, Hüsing T, Reime S, Nolze A, Maschek M, Thews O & Riemann A. J Exp Clin Cancer Res, 40:10
SMARCB1 Promotes Ubiquitination and Degradation of NR4A3 via Direct Interaction Driven by ROS in Vascular Endothelial Cell Injury (2020). Lu B, et. al. Oxid Med Cell Longev. 2020 Oct 23;2020:2048210
Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer (2020). Malier M, Court M, Gharzeddine K, Laverierre M-H, Marsili S, Thomas F, Decaens T, Roth G & Millet A. www.biorxiv.org/content/10.1101/2020.10.15.341123v1
Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts (2020). Kozlov AM, Lone A, Betts DH & Cumming RC. Nature Scientific Reports 10, 8388
Hypercapnia potentiates HIF-1α activation in the brain of rats exposed to intermittent hypoxia (2020). Tregubab PP, Malinovskayaa NA, Morguna AV, Osipovaa ED, Kulikovb VP, Kuzovkova DA, and Kovzelevc PD. J. Resp 278, 103442
Inhibition of Carbonic Anhydrase IX by Ureidosulfonamide Inhibitor U104 Reduces Prostate Cancer Cell Growth.... (2019). Riemann A, Güttler A, Haupt V, Wichmann H, Reime S, Bache M, Vordermark D and Thews O. Oncology Research
Proteomic Analysis of Human Macrophage Polarization Under a Low Oxygen Environment (2019). Court M, Malier M and Millet A. J. Vis. Exp.
The effect of hypoxia on ZEB1 expression in a mimetic system of the blood-brain barrier (2018). Leduc-Galindo D, Qvist P, Tóth AE, Fryland T, Nielsen MS, B?rglum AD and Christensen JH. Microvascular Research
Acidic extracellular environment affects miRNA expression in tumors in vitro and in vivo (2018). Riemann A, Reime S, and Thews O. Int J Cancer
Induction and Assessment of Hypoxia in Glioblastoma Cells In Vitro (2018). Gagner JP, Lechpammer M and Zagzag D. Methods Mol Biol.
Tumor Acidosis and Hypoxia Differently Modulate the Inflammatory Program: Measurements In Vitro and In Vivo (2017). Riemann A, Reime S and Thews O. Neoplasia
Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1 (2017). Kulkarni A, Mateus M, Thinnes CC, McCullagh JS, Schofield CJ, Taylor GP and Bangham CRM. Cell Chemical Biology
